Also, it would be important to check whether the data is cached anywhere, or streamed directly to people's web apps - if it's cached (as I suspect it might be) then setting it excessively high might be open to abuse.
Unfortunately there probably use legitimate use-cases for large uploads, such as an online gallery where users can upload a large zip file of photos. These cases are probably rare enough that it's worth waiting to see whether any pop up in practice, though. Might be worth a FAQ entry in the meantime (probably a generic "what are the system limits" entry which covers upload sizes, request header limits, disk quotas, etc.)